Back to article: Acyl-CoA-binding protein (ACBP): the elusive ‘hunger factor’ linking autophagy to food intake

FIGURE 3: The ‘hunger reflex'. Hypothetical explanation of the pathogenesis of obesity. Extracellular ACBP/DBI participates in a short-term homeostatic feedback loop to link starvation to food intake. However, obesity causes an increase in ACBP/DBI expression and its spontaneous release that leads to chronic hyperphagy, thus locking the disease in a pathogenic feedforward loop.

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