Back to article: p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway


FIGURE 1: p38 promotes PDCD4 degradation. (A) Bone marrow-derived macrophages (BMDMs) were treated with BIRB796 (BIRB) as depicted and then stimulated with LPS or anisomycin (Aniso) only for 4 hours. (B) p38fl/fl and p38αΔM BMDMs were stimulated with Aniso or LPS for 4 hours. (C) Mk2-/- macrophages reconsti-tuted with either MK2 K79M mutant or WT MK2 were stimulated with Aniso or LPS for 4 hours. Cell lysates were analyzed by im-munoblotting.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.

Close