Back to article: STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

FIGURE 2: Cell-intrinsic STING activation effects on T cells. Direct stimulation of T cells by STING ligands can produce contrasting effects. Mild activation levels of STING signaling can be exploited to boost TH1 and TH9 differentiation [55]. Impaired STING signaling in T cells results in reduced frequency of central memory CD8+ T cells, reduced proliferation, and reduced effector functions upon adoptive transfer [56]. Potent STING signaling results in reduced proliferation and induction of cell death by apoptosis [53][54].

53. Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A (2017). Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death. J Immunol 199(2): 397-402. 10.4049/jimmunol.1601999

54. Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A (2017). Signalling strength determines proapoptotic functions of STING. Nat Commun 8(1): 427. 10.1038/s41467-017-00573-w

55. Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L (2022). CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells. J Immunother Cancer 10(1): e003459. 10.1136/jitc-2021-003459

56. Li W, Lu L, Lu J, Wang X, Yang C, Jin J, Wu L, Hong X, Li F, Cao D, Yang Y, Wu M, Su B, Cheng J, Yang X, Di W, Deng L (2020). cGAS-STING-mediated DNA sensing maintains CD8(+) T cell stemness and promotes antitumor T cell therapy. Sci Transl Med 12(549): eaay9013. 10.1126/scitranslmed.aay9013

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