Reviews:
Cell Stress, Vol. 9, No. 1, pp. 174 - 181; doi: 10.15698/cst2025.08.309
Role of mitochondrial dysfunction in ocular surface diseases
1 Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. 2 Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China. 3 Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, 200032, China. 4 NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai, 200031, China. 5 Department of Ophthalmology, Children’s Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China.
Keywords: mitochondrial dysfunction, the ocular surface diseases, dry eye, Fuchs endothelial cell dys-trophy.
Received originally: 14/12/2024 Received in revised form: 20/05/2025
Accepted: 03/06/2025
Published: 05/08/2025
Correspondence:
Qihua Le, Department of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83, Fen Yang Road, Shanghai, 200031, China; qihuale_eent@163.com
Jiaxu Hong, Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, 200032, China; jiaxu.hong@fdeent.org
Conflict of interest statement:
Please cite this article as: Xiaohan Chen, Jiaxu Hong and Qihua Le (2025). Role of mitochon-drial dysfunction in ocular surface diseases. Cell Stress9:174-181. doi: 10.15698/cst2025.08.309
Abstract
The dysfunction of mitochondria, the “energy factories” of cells, not only causes an insufficiency of energy production but also leads to various pathological alterations in cells such as the accumulation of reactive oxygen species, inflammatory responses and mitochondrial DNA damage, all of which were involved in the onset or deterioration of diseases. The presence of mitochondrial dysfunction has been confirmed in many ocular surface diseases such as dry eye, Fuchs corneal endothelial dystrophy and diabetic keratopathy. However, its role in the pathogenesis of ocular surface diseases and underlying molecular mechanisms have not been fully elucidated. Moreover, mitochondrial therapies for ocular surface diseases are currently still under investigation. This mini-review summarizes the pathological features of mitochondrial dysfunction and its mechanisms that have been identified in the pathogenesis of ocular surface diseases, and discusses the potential of mitochondrial therapies in the treatment of these diseases.
For full text please see pdf.
ACKNOWLEDGMENTS
We would like to express our sincere gratitude to Chuwei Lu and Yan Shen for their technical support. There's none financial disclosure. The study is supported by the Natural Science Foundation of China (82471042) and the Natural Science Foundation of Shanghai (24ZR1409600).
COPYRIGHT
© 2025
Role of mitochondrial dysfunction in ocular surface diseases by Chen et al. is licensed under a Creative Commons Attribution 4.0 International License.
