FIGURE 1: Proposed model of MiT/TFE–mediated trans­criptional regulation of mTORC1 signaling according to nutritional status. Starvation switches off mTORC1 and MiT/TFE TFs translocate to the nucleus where they promote expression of genes involved in catabolic pathways as well as RagD GTPase, thus promoting the assembly of inactive Rags heterodimers on the lysosome. Feeding turns on RagGTPases, which can now efficiently recruit mTORC1 to the lysosome and promote its activation. This mechanism enables the cell to efficiently switch between catabolism and anabolism according nutrient availability.