Table of contents

Volume 5, Issue 8, pp. 119 - 127, August 2021

Issue cover
Cover: This month in Cell Stress: Cytoskeleton-associated protein PDLIM1 in cancer. Image depicts actin cytoskeleton (orange) and nucleus (teal) staining. Public domain image by Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, National Institutes of Health. The cover is published under the CC BY 4.0 license. Enlarge issue cover


PDLIM1: Structure, function and implication in cancer

Jian-Kang Zhou, Xin Fan, Jian Cheng, Wenrong Liu and Yong Peng

page 119-127 | 10.15698/cst2021.08.254 | Full text | PDF | Abstract

PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.

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