This month in Cell Stress: Gamma secretase in Alzheimer’s disease. Image depicts a transmembrane surface display of the human gamma-secretase structure. Image from the RCSB PDB of PDB ID 5A63 by Bai, X., Yan, C., Yang, G., Lu, P., Ma, D., Sun, L., Zhou, R., Scheres, S.H.W., Shi, Y. (2015) Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. Nature 525: 212. Background image from pexels.com. Images modified by Cell Stress. The cover is published under the CC BY 4.0 license.