Table of contents

Volume 7, Issue 1, pp. 1 - 6, January 2023

Issue cover
Cover: This month in Cell Stress: Deconstructing nutritional research to improve reproducibility. Composite image via by users Thirdman and Geraud Pfeiffer. Images modified by Cell Stress. The cover is published under the CC BY 4.0 license. Enlarge issue cover


Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Maria Castedo, Antoine Lafarge and Guido Kroemer

page 1-6 | 10.15698/cst2023.01.275 | Full text | PDF | Abstract

The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.

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