Table of contents

Volume 7, Issue 3, pp. 12 - 19, March 2023

Issue cover
Cover: This month in Cell Stress: Role of microbiota in breast cancer therapy. Public domain image depticting small intestine section from "Biology and Man" (1944), by Benjamin C. Gruenberg, & N. Eldred Bingham via Image modified by Cell Stress. The cover is published under the CC BY 4.0 license. Enlarge issue cover


Impact of microbiota on breast cancer hormone therapy

Safae Terrisse, Laurence Zitvogel and Guido Kroemer

page 12-19 | 10.15698/cst2023.03.277 | Full text | PDF | Abstract

Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters. Thus, the immunosurveillance system retards the development of hormone-positive breast cancer and contributes to the therapeutic efficacy of estrogen receptor antagonists and aromatase inhibitors. Moreover, the anticancer immune response is profoundly modulated by the local and intestinal microbiota, which influences cancer cell-intrinsic signaling pathways, affects the composition and function of the immune infiltrate present in the tumor microenvironment and modulates the metabolism of estrogens. Indeed, specific bacteria in the gut produce enzymes that affect the enterohepatic cycle of estrogen metabolites, convert estrogens into androgens or generate estrogen-like molecules. The knowledge of these circuitries is in its infancy, calling for further in-depth analyses.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.