Back to article: Molecular targets of spermidine: implications for cancer suppression

FIGURE 1: Model for spermidine-mediated effects in immune and cancer cells. Systemically supplied spermidine elicits antitumor responses predominantly through targeting pathways that improve immune cell function (blue arrows). However, in cancer cells or the tumor microenvironment regulation of these targets by endogenous polyamine biosynthesis may also promote proliferation and cancer cell survival (red arrows). See text for details. MTP, mitochondrial trifunctional protein. FAO, fatty acid oxidation. eIF5AH, hypusinated eukaryotic initiation factor 5A. TFEB, transcription factor EB. EP300, histone acetyltransferase E1A binding protein P300. NMDAR, N-methyl aspartate receptor. hCA, human carbonic anhydrase. LSD1, lysine-specific histone demethylase 1. ATP, adenosine triphosphate. Illustration generated with Biorender.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.