FIGURE 1: Specific neurons and neural circuits in Drosophila are more sensitive to reduction of Lamin levels. Schematic diagram of the adult fly central nervous system (brain and thoracicoabdominal ganglion) highlighting the neurons and neural circuits that were studied in Oyston et al. 2018. Eyes, antennae and certain muscles are also depicted as landmarks. For simplicity, only one side of the bilateral giant fiber system is shown here. Flies with decreased neuronal Lamin expression exhibited age-dependent motor deficits and shortened life span. The authors observed histological or functional defects in PAM (protocerebral anterior medial) cluster dopaminergic neurons and in escape response mediating neuronal circuits composed of giant fiber neurons, peripherally synapsing interneurons (PSI) and dorsal longitudinal motor neurons (DLMn). In contrast, non-PAM cluster dopaminergic neurons and a parallel giant fiber circuit comprised of tergo-trochanteral motor neurons (TTMn) were not affected.