Back to article: Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model

FIGURE 1: Proposed anti-proliferative signaling mechanism in response to mitochondrial inhibition. Inhibition of mitochondrial respiration genetically (Polgmut/mut) or pharmacologically (metformin) can delay tumorigenesis in association with induction of autophagy and GSK3-mediated suppression of cyclin D1 to affect cell cycle progression.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.