Back to article: Tissue-resident memory T cells orchestrate tumour-immune equilibrium

FIGURE 2: Tissue-resident memory T cells (TRM) suppress the outgrowth of persisting melanoma cells and promote a state of melanoma-immune equilibrium. This mode of tumour control is highly localised and does not rely on recirculating T cells (TCIRC). Putative effector pathways operating during melanoma-immune equilibrium include the TRM-derived cytokines TNFα and IFNγ, as well as the cytotoxic effector molecule perforin. While TNFα appears to play a dominant role, the contribution of the other effector molecules may be redundant.

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