Back to article: Remodeling of mitochondrial morphology and function: an emerging hallmark of cellular reprogramming

FIGURE 2: Scheme of the mitochondrial pathway of apoptosis. Stress-induced activation of BAX/BAK leading to mitochondrial outer membrane permeabilization and cytochrome c release to the cytosol. Anti-apoptotic proteins block BAK/BAX activation/oligomerization induced by BH3-only proteins. BCL-XL: B-cell lymphoma extra-large; MCL-1: myeloid cell leukemia 1; BID: BH3-interacting domain death agonist; BIM: BCL-2 interacting mediator of cell death; PUMA: P53-upregulated modulator of apoptosis.

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