Back to article: A mutant p53/Hif1α/miR-30d axis reprograms the secretory pathway promoting the release of a prometastatic secretome

FIGURE 1: Impact of the mut-p53 secretome on the TME. mut-p53 in cooperation with HIF1α is able to bind MIR30D promoter and activate the expression of miR-30d. By targeting the diacylglycerol kinase ζ (DGKZ), miR-30d fosters diacylglycerol DAG signaling in the Golgi Apparatus, causing morphological and functional alterations (i.e. Golgi tubulo-vesiculation), responsible for the increase in total protein secretion. The mut-p53 driven secretome, including soluble factors and extracellular matrix (ECM) components, induces tumor cell invasion and migration, angiogenesis, alteration of mechanical properties of the ECM and fibroblasts activation. Altogether these TME features sustain tumor progression and metastasis.

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