Back to article: MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression

FIGURE 5: Effects of fibroblast miR-200c in vitro on features of cancer aggressiveness. (A-C) Flow data showed functional mitochondrial mass, apoptosis and proliferation in cancer cells co-cultured with F200c. (D) S phase of MCF7 cells in homotypic culture or co-culture with miR-200c BJ1 fibroblasts and controls, with and without Tamoxifen treatment for 24 hours. (E) Wound healing. Wound gap area of MCF7 cells exposed to conditioned media from BJ1 miR-200c or control at time points 0 and 16 hours post-exposure. (F) PD-L1 expression in MCF7 and AT3 cancer cells under homotypic and co-culture with miR200c fibroblasts or controls. *p<0.05. (G) Correlation between CCL5 and PD-L1.

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