Back to article: MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression

FIGURE 7: Effect of miR-200c in fibroblasts on resistance to chemo-immuno-therapy. (A) Representative PD-L1 staining in tumor sections. Co-injection of 4T1 cells and miR-200c NIH3T3 fibroblasts or controls (scale bar: 20μm). Immunohistochemistry quantification for PD-L1 in random units as per ImageJ quantification. (B-D) Co-injection with AT3 cells and MEFs miR-200c or control. (B) PD-L1 immunoblot. (C, D) Tumor growth with chemo-immunotherapy. Mice were treated by IP with Paclitaxel and anti-PD-L1 versus DMSO and control IgG after tumor implantation.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.