Back to article: GFI1’s role in DNA repair suggests implications for tumour cell response to treatment
FIGURE 1: Model for the action of GFI1 in DNA repair. GFI1 acts as a bridge between the PRMT1 methyltransferase and key DNA repair proteins to promote their activity. Methylation of MRE11 and the corresponding facilitation of HR repair are shown as an example of this activity of GFI1.