Back to article: Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

FIGURE 5: FAD mutations in presenilin. Schematic representation of the nine TMD structure of presenilin in its cleaved form with the NTF (blue) and CTF (cyan). Pathogenic presenilin mutations ( are found in all TMDs and in some of the HLs. The compared to PS1 less frequent PS2 FAD mutations are represented in italics. The red arrow indicates the site of endoproteolysis.

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