Back to article: The emerging role of minor intron splicing in neurological disorders

Table 1. Major vs Minor spliceosome snRNAs and associated pro-teins.

+Sm proteinsB/B’, D1, D2, D3, E, F, and G

*U5 snRNA is shared between major and minor spliceosomes

# Denotes the centrifugal fraction in which the proteins were identified

Note: Dynamic changes in protein compositions of the snRNPs during splicing stages are not shown and the reader is referred to [13, 14] for more details.

4. Turunen JJ, Niemela EH, Verma B, Frilander MJ (2013). Turunen JJ, Niemela EH, Verma B, Frilander MJ. Wiley Interdiscip Rev RNA 4(1): 61-76.

13. Will CL, Luhrmann R (2011). ). Spliceosome structure and function. Cold Spring Harb Perspect Biol 3(7).

14. Wahl MC, Will CL, Luhrmann R (2009). The spliceosome: design principles of a dynamic RNP machine.. Cell 136(4): 701-718.

15. Heinrichs V, Bach M, Winkelmann G, Luhrmann R (1990). U1-specific protein C needed for efficient complex formation of U1 snRNP with a 5′ splice site. Science 247(4938): 69-72.

16. Pettersson I, Hinterberger M, Mimori T, Gottlieb E, Steitz JA (1984). The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies. J Biol Chem 259(9): 5907-5914.

17. Will CL, Luhrmann R (1997). Protein functions in pre-mRNA splicing. Curr Opin Cell Biol 9(3): 320-328.

18. Behrens SE, Tyc K, Kastner B, Reichelt J, Luhrmann R (1993). Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions. Mol Cell Biol 13(1): 307-319.

19. Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Luhrmann R, Query CC (2001). A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. EMBO J 20(16): 4536-4546.

20. Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (1998). The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. Mol Cell Biol 18(11): 6756-6766.

21. Bach M, Winkelmann G, Luhrmann R (1989). 20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition. Proc Natl Acad Sci U S A 86(16): 6038-6042.

22. . Schneider C, Will CL, Makarova OV, Makarov EM, Lührmann R (2002). Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Mol Cell Biol 22(10): 3219-3229.

24. Will CL, Schneider C, Reed R, Lührmann R (1999). Identification of both shared and distinct proteins in the major and minor spliceosomes. Science 284(5422): 2003-2005.

25. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (2004). The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA 10(6): 929-941.

23. Nottrott S, Urlaub H, Luhrmann R (2002). Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins.. EMBO J 21(20): 5527-5538.

26. Lorkovic ZJ, Lehner R, Forstner C, Barta A (2005). Evolutionary conservation of minor U12-type spliceosome between plants and humans. RNA 11(7): 1095-1107.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.