FIGURE 3: The function of Snap29 during autophagy. Snap29 associates to Syx17, which is recruited from the ER to nascent autophagosomes to regulate their fusion with lysosomes, with the help of Atg14 polymers. O-GlcNac modification of Snap29 in high nutrient conditions prevent inclusion in an fusion complex (A). Fusion involves the HOPS and BORC tethering complexes, Epg5 and Rab7 (B). Snap29, Syx17, Vamp8 and the HOPS complex are also used in fusion of mitochondrial-derived vesicles with lysosomes (C) (see text for details).