Table of contents

Volume 6, Issue 10, pp. 79 - 88, October 2022

Issue cover
Cover: Artist's illustration of heart coronary artery lesion. Credit: By Patrick J. Lynch, medical illustrator - Patrick J. Lynch, medical illustrator, CC BY 2.5. Image modified by Cell Stress. The cover is published under the CC BY 4.0 license. Enlarge issue cover

Reviews

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun

page 79-88 | 10.15698/cst2022.10.272 | Full text | PDF | Abstract

Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.

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