FIGURE 3: Hypothalamic miRNAs control energy balance. POMC and AgRP neurons from the arcuate nucleus (ARC) send projections to the paraventricular nucleus (PVN) to control energy balance. Dicer and several miRNAs, such as miR-103 and miR-200a, have been proposed to control appetite and body weight likely via POMC neurons. Additionally, miRNA biogenesis is also important for the development of POMC neurons. Melanocortin receptor 4 (MC4R).