Back to article: Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma

FIGURE 1: The interconnected OG-TSG CBs operate in renal epithelium to control signaling output and prevent tumorigenesis. (A) Depicts the physiological employment of the inherent VHL-HIF CB to gauge tissue response to low oxygen tension, and (B-D) examine how the sequential losses of a pre-determined set of “OG-TSG CBs” once the first CB is inactivated result in ccRCC.

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