Back to article: Emerging roles of mitochondria and autophagy in liver injury during sepsis


Table 1. Chemicals that affect liver injury during sepsis by modulating autophagy.

25. Hsieh CH, Pai PY, Hsueh HW, Yuan SS, Hsieh YC (2011). Complete induction of autophagy is essential for cardioprotection in sepsis. Ann Surg 253(6): 1190-1200. https://doi.org/10.1097/SLA.0b013e318214b67e

49. Rah SY, Lee YH, Kim UH (2017). NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J https://doi.org/10.1096/fj.201601290R

51. Cho HI, Kim SJ, Choi JW, Lee SM (2016). Genipin alleviates sepsis-induced liver injury by restoring autophagy. Br J Pharmacol 173(6): 980-991. https://doi.org/10.1111/bph.13397

52. Li Y, Wang X, Wei Z, Mao H, Gao M, Liu Y, Ma Y, Liu X, Guo C, Zhang L (2014). Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury. Biochem Biophys Res Commun 455(3-4): 234-240.https://doi.org/10.1016/j.bbrc.2014.10.152

53. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida K, Uemura K (2013). Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res 43(1): 91-96.https://doi.org/10.1111/j.1872-034X.2012.01049.x

54. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS (2011). Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 53(6): 2053-2062.https://doi.org/10.1002/hep.24324

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