Back to article: Mechanisms and therapeutic significance of autophagy modulation by antipsychotic drugs

Table 1. Modulation of neuronal/brain autophagy by antipsychotics.

“Flux” refers to autophagic flux; ↑ denotes increase/activation; ↓ denotes de-crease/inhibition; n.a. – not assessed; AMPK – AMP-activated protein kinase; ATG – autophagy related; DA – dopaminergic; PINK1 – Phosphatase and tensin homolog -induced kinase 1; ROS – reactive oxygen species; TDP43 – TAR DNA-binding protein 43; TFEB – transcription factor EB; ULK1 – Unc-51 like autophagy activating kinase.

16. Kim YD, Jeong EI, Nah J, Yoo SM, Lee WJ, Kim Y, Moon S, Hong SH, Jung YK (2017). Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate-activated protein kinase-mediated autophagy. J Neurochem 142(5): 734-746.

17. Shin JH, Park SJ, Kim ES, Jo YK, Hong J, Cho DH (2012). Sertindole, a potent antagonist at dopamine D(2) receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells. Biol Pharm Bull 35(7): 1069-1075.

18. Vucicevic L, Misirkic-Marjanovic M, Paunovic V, Kravic-Stevovic T, Martinovic T, Ciric D, Maric N, Petricevic S, Harhaji-Trajkovic L, Bumbasirevic V, Trajkovic V (2014). Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy 10(12): 2362-2378.

19. Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D (2017). Rescue of Pink1 defi-ciency by stress-dependent activation of autophagy. Cell Chem Biol 24(4): 471-480 e474.

20. Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S (2014). Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol 35(7): 1700-1711.

21. Hollerhage M, Goebel JN, de Andrade A, Hildebrandt T, Dolga A, Culmsee C, Oertel WH, Hengerer B, Hoglinger GU (2014). Trifluoperazine rescues human dopaminergic cells from wild-type alpha-synuclein-induced toxicity. Neurobiol Aging 10(8): 677-685.

23. Kim SH, Park S, Yu HS, Ko KH, Park HG, Kim YS (2018). The antipsychotic agent clozapine induces autophagy via the AMPK-ULK1-Beclin1 signaling pathway in the rat frontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 81:96-104.

24. Park J, Chung S, An H, Kim J, Seo J, Kim DH, Yoon SY (2012). Haloperidol and clozapine block formation of autophagolyso-somes in rat primary neurons. Neuroscience 209: 64-73.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.